4-hydroxybenzoyl-CoA thioesterase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxybenzoyl-CoA thioesterase (EC 3.1.2.23) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzoyl-CoA + H₂O $\rightleftharpoons$ 4-hydroxybenzoate + CoA

Thus, the two substrates of this enzyme are 4-hydroxybenzoyl-CoA and H₂O, whereas its two products are 4-hydroxybenzoate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 4-hydroxybenzoyl-CoA hydrolase. This enzyme participates in 2,4-dichlorobenzoate degradation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1HN1, 1LO7, 1LO8, 1LO9, 1Q4S, 1Q4T, and 1Q4U.

[edit] References

IUBMB entry for 3.1.2.23
BRENDA references for 3.1.2.23 (Recommended.)
PubMed references for 3.1.2.23
PubMed Central references for 3.1.2.23
Google Scholar references for 3.1.2.23
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D (1992). "Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3". Biochemistry. 31: 5605–10. PMID 1610806.
Dunaway-Mariano D, Babbitt PC (1994). "On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway". Biodegradation. 5: 259–76. PMID 7765837.