4-hydroxybenzoyl-CoA reductase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC 1.3.99.20) is an enzyme that catalyzes the chemical reaction

benzoyl-CoA + acceptor + H₂O $\rightleftharpoons$ 4-hydroxybenzoyl-CoA + reduced acceptor

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H₂O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1RM6 and 1SB3.

[edit] References

IUBMB entry for 1.3.99.20
BRENDA references for 1.3.99.20 (Recommended.)
PubMed references for 1.3.99.20
PubMed Central references for 1.3.99.20
Google Scholar references for 1.3.99.20
Glockler R, Tschech A, Fuchs G (1989). "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS. Lett. 251: 237–40. doi:10.1016/0014-5793(89)81461-9. PMID 2753161.
G, Fuchs G (1998). "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170: 120–31. doi:10.1007/s002030050623. PMID 9683649.
Breese K, Fuchs G (1998). "4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins". Eur. J. Biochem. 251: 916–23. doi:10.1046/j.1432-1327.1998.2510916.x. PMID 9490068.
Brackmann R, Fuchs G (1993). "Enzymes of anaerobic metabolism of phenolic compounds 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species". Eur. J. Biochem. 213: 563–71. doi:10.1111/j.1432-1033.1993.tb17795.x. PMID 8477729.
Heider J, Fuchs G (1997). "Anaerobic metabolism of aromatic compounds". Eur. J. Biochem. 243: 577–96. doi:10.1111/j.1432-1033.1997.00577.x. PMID 9057820.