4-hydroxybenzoate nonaprenyltransferase

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In enzymology, a 4-hydroxybenzoate nonaprenyltransferase (EC 2.5.1.39) is an enzyme that catalyzes the chemical reaction

solanesyl diphosphate + 4-hydroxybenzoate $\rightleftharpoons$ diphosphate + nonaprenyl-4-hydroxybenzoate

Thus, the two substrates of this enzyme are solanesyl diphosphate and 4-hydroxybenzoate, whereas its two products are diphosphate and nonaprenyl-4-hydroxybenzoate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase. Other names in common use include nonaprenyl-4-hydroxybenzoate transferase, 4-hydroxybenzoate transferase, p-hydroxybenzoate dimethylallyltransferase, p-hydroxybenzoate polyprenyltransferase, p-hydroxybenzoic acid-polyprenyl transferase, and p-hydroxybenzoic-polyprenyl transferase. This enzyme participates in ubiquinone biosynthesis.

[edit] References

IUBMB entry for 2.5.1.39
BRENDA references for 2.5.1.39 (Recommended.)
PubMed references for 2.5.1.39
PubMed Central references for 2.5.1.39
Google Scholar references for 2.5.1.39
Kalen A, Appelkvist EL, Chojnacki T, Dallner G (1990). "Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver". J. Biol. Chem. 265: 1158–64. PMID 2295606.