4-hydroxybenzoate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxybenzoate-CoA ligase (EC 6.2.1.27) is an enzyme that catalyzes the chemical reaction

ATP + 4-hydroxybenzoate + CoA AMP + diphosphate + 4-hydroxybenzoyl-CoA

The 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-hydroxybenzoate:CoA ligase (AMP-forming). Other names in common use include 4-hydroxybenzoate-CoA synthetase, 4-hydroxybenzoate-coenzyme A ligase (AMP-forming), 4-hydroxybenzoyl coenzyme A synthetase, and 4-hydroxybenzoyl-CoA ligase. This enzyme participates in benzoate degradation via coa ligation.

[edit] References

• IUBMB entry for 6.2.1.27
• BRENDA references for 6.2.1.27 (Recommended.)
• PubMed references for 6.2.1.27
• PubMed Central references for 6.2.1.27
• Google Scholar references for 6.2.1.27
• Merkel SM, Eberhard AE, Gibson J, Harwood CS (1989). "Involvement of coenzyme A thioesters in anaerobic metabolism of 4-hydroxybenzoate by Rhodopseudomonas palustris". J. Bacteriol. 171: 1–7. PMID 2914844. 

[edit] External links

The CAS registry number for this enzyme class is 119699-80-8.

• IUBMB entry for 6.2.1.27

• KEGG entry for 6.2.1.27

• BRENDA entry for 6.2.1.27

• NiceZyme view of 6.2.1.27

• EC2PDB: PDB structures for 6.2.1.27

• PRIAM entry for 6.2.1.27

• PUMA2 entry for 6.2.1.27

• IntEnz: Integrated Enzyme entry for 6.2.1.27

• MetaCyc entry for 6.2.1.27

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018859: 4-hydroxybenzoate-CoA ligase

• AMIGO entry for GO code 0018859: 4-hydroxybenzoate-CoA ligase