4-hydroxybenzaldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxybenzaldehyde dehydrogenase (EC 1.2.1.64) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzaldehyde + NAD⁺ + H₂O 4-hydroxybenzoate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-hydroxybenzaldehyde, NAD⁺, and H₂O, whereas its 3 products are 4-hydroxybenzoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p-hydroxybenzaldehyde dehydrogenase. This enzyme participates in toluene and xylene degradation.

[edit] References

• IUBMB entry for 1.2.1.64
• BRENDA references for 1.2.1.64 (Recommended.)
• PubMed references for 1.2.1.64
• PubMed Central references for 1.2.1.64
• Google Scholar references for 1.2.1.64
• Bossert ID, Whited G, Gibson DT, Young LY (1989). "Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium". J. Bacteriol. 171: 2956–62. PMID 2722739. 
• Whited GM, Gibson DT (1991). "Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1". J. Bacteriol. 173: 3017–20. PMID 2019564. 

[edit] External links

• IUBMB entry for 1.2.1.64

• KEGG entry for 1.2.1.64

• BRENDA entry for 1.2.1.64

• NiceZyme view of 1.2.1.64

• EC2PDB: PDB structures for 1.2.1.64

• PRIAM entry for 1.2.1.64

• PUMA2 entry for 1.2.1.64

• IntEnz: Integrated Enzyme entry for 1.2.1.64

• MetaCyc entry for 1.2.1.64

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018484: 4-hydroxybenzaldehyde dehydrogenase

• AMIGO entry for GO code 0018484: 4-hydroxybenzaldehyde dehydrogenase