4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

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In enzymology, a 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17) is an enzyme that catalyzes the chemical reaction

4-deoxy-L-threo-5-hexosulose uronate 3-deoxy-D-glycero-2,5-hexodiulosonate

Hence, this enzyme has one substrate, 4-deoxy-L-threo-5-hexosulose uronate, and one product, 3-deoxy-D-glycero-2,5-hexodiulosonate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase. This enzyme is also called 4-deoxy-L-threo-5-hexulose uronate isomerase. This enzyme participates in pentose and glucuronate interconversions.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1X8M, 1XRU, and 1YWK.

[edit] References

• IUBMB entry for 5.3.1.17
• BRENDA references for 5.3.1.17 (Recommended.)
• PubMed references for 5.3.1.17
• PubMed Central references for 5.3.1.17
• Google Scholar references for 5.3.1.17
• Preiss J (1966). "4-Deoxy-L-threo-5-hexosulose uronic acid isomerase". Methods Enzymol. 9: 602–604. 

[edit] External links

The CAS registry number for this enzyme class is 37318-44-8.

• IUBMB entry for 5.3.1.17

• KEGG entry for 5.3.1.17

• BRENDA entry for 5.3.1.17

• NiceZyme view of 5.3.1.17

• EC2PDB: PDB structures for 5.3.1.17

• PRIAM entry for 5.3.1.17

• PUMA2 entry for 5.3.1.17

• IntEnz: Integrated Enzyme entry for 5.3.1.17

• MetaCyc entry for 5.3.1.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008697: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

• AMIGO entry for GO code 0008697: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase