4-Deoxypyridoxine
From Wikipedia, the free encyclopedia
| 4-Deoxypyridoxine | |
|---|---|
 |
|
| Identifiers | |
| CAS number | [148-51-6] |
| PubChem | |
| SMILES | CC1=C(C(=NC=C1CO)C)O |
| Properties | |
| Molecular formula | C8H11NO2 |
| Molar mass | 153.178 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
|
4-Deoxypyridoxine is a vitamin B6 antagonist.[1] It may be toxic to developing embryos since it can have negative effects on collagen and elastin during development.[2] The presence of this compound can produce vitamin B6 deficiency, which suppresses the immune system.[3] This immunosuppression can be beneficial in animal models of Trichinella spiralis infections.[4]
[edit] References
- ^ Coburn SP, Mahuren JD, Schaltenbrand WE, Wostmann BS, Madsen D (1981). "Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat". J. Nutr. 111 (2): 391–8. PMID 6257871.
- ^ Bird TA, Levene CI (1983). "The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo". Biochem. J. 210 (3): 633–8. PMID 6135414.
- ^ Trakatellis A, Dimitriadou A, Exindari M, et al (1992). "Effect of pyridoxine deficiency on immunological phenomena". Postgrad Med J 68 Suppl 1: S70–7. PMID 1409221.
- ^ Frydas S, Papaioanou N, Vlemmas I, et al (1999). "Vitamin B6-deficient diet plus 4-deoxypyridoxine (4-DPD) reduces the inflammatory response induced by T. spiralis in diaphragm, masseter and heart muscle tissue of mice". Mol. Cell. Biochem. 197 (1-2): 79–85. PMID 10485327.
