4-chlorobenzoate dehalogenase

From Wikipedia, the free encyclopedia

In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + H₂O 4-hydroxybenzoate + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoate and H₂O, whereas its two products are 4-hydroxybenzoate and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.

[edit] References

• IUBMB entry for 3.8.1.6
• BRENDA references for 3.8.1.6 (Recommended.)
• PubMed references for 3.8.1.6
• PubMed Central references for 3.8.1.6
• Google Scholar references for 3.8.1.6
• Muller R, Thiele J, Klages U, Lingens F (1984). "Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3". Biochem. Biophys. Res. Commun. 124: 178–82. PMID 6497878. 
• Heppel LA and Porterfield VT (1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds". J. Biol. Chem. 176: 763–769. 

[edit] External links

The CAS registry number for this enzyme class is 94047-11-7.

• IUBMB entry for 3.8.1.6

• KEGG entry for 3.8.1.6

• BRENDA entry for 3.8.1.6

• NiceZyme view of 3.8.1.6

• EC2PDB: PDB structures for 3.8.1.6

• PRIAM entry for 3.8.1.6

• PUMA2 entry for 3.8.1.6

• IntEnz: Integrated Enzyme entry for 3.8.1.6

• MetaCyc entry for 3.8.1.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047576: 4-chlorobenzoate dehalogenase

• AMIGO entry for GO code 0047576: 4-chlorobenzoate dehalogenase