4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) is an enzyme that catalyzes the chemical reaction

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol $\rightleftharpoons$ ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thus, the two substrates of this enzyme are ATP and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, whereas its two products are ADP and 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase. This enzyme participates in biosynthesis of steroids.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1OJ4, 1UEK, 2V2Q, 2V2V, 2V2Z, 2V34, and 2V8P.

[edit] References

IUBMB entry for 2.7.1.148
BRENDA references for 2.7.1.148 (Recommended.)
PubMed references for 2.7.1.148
PubMed Central references for 2.7.1.148
Google Scholar references for 2.7.1.148
Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W (2000). "Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol". Proc. Natl. Acad. Sci. U. S. A. 97: 1062–7. doi:10.1073/pnas.97.3.1062. PMID 10655484.
Seto H (2000). "Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase". Tetrahedron Lett. 41: 2925–2928. doi:10.1016/S0040-4039(00)00295-1.