3beta-hydroxy-Delta5-steroid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 3beta-hydroxy-Delta5-steroid dehydrogenase (EC 1.1.1.145) is an enzyme that catalyzes the chemical reaction

a 3beta-hydroxy-Delta₅-steroid + NAD⁺ a 3-oxo-Delta₅-steroid + NADH + H⁺

Thus, the two substrates of this enzyme are 3beta-hydroxy-Delta5-steroid and NAD⁺, whereas its 3 products are 3-oxo-Delta5-steroid, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase. Other names in common use include progesterone reductase, Delta5-3beta-hydroxysteroid dehydrogenase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-Delta5-C27-steroid oxidoreductase, 3beta-hydroxy-5-ene-steroid oxidoreductase, steroid-Delta5-3beta-ol dehydrogenase, 3beta-HSDH, 5-ene-3-beta-hydroxysteroid dehydrogenase, and 3beta-hydroxy-5-ene-steroid dehydrogenase. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.

[edit] References

• IUBMB entry for 1.1.1.145
• BRENDA references for 1.1.1.145 (Recommended.)
• PubMed references for 1.1.1.145
• PubMed Central references for 1.1.1.145
• Google Scholar references for 1.1.1.145
• Cheatum SG, Watten JC (1966). "Purification and properties of 3-beta-hydroxysteroid dehydrogenase and delta-5-3-ketosteroid isomerase from bovine corpora lutea". Biochim. Biophys. Acta. 122: 1–13. PMID 4226148. 
• Koritz SB (1964). "The conversion of prepnenolone to progesterone by small particle from rat adrenal". Biochemistry 3: 1098–1102. doi:10.1021/bi00896a015. 
• Neville AM, Orr, JC and Engel LL (1968). "Delta5-3beta-Hydroxy steroid dehydrogenase activities of bovine adrenal cortex". Biochem. J. 107: 20. 

[edit] External links

The CAS registry number for this enzyme class is 9044-85-3.

• IUBMB entry for 1.1.1.145

• KEGG entry for 1.1.1.145

• BRENDA entry for 1.1.1.145

• NiceZyme view of 1.1.1.145

• EC2PDB: PDB structures for 1.1.1.145

• PRIAM entry for 1.1.1.145

• PUMA2 entry for 1.1.1.145

• IntEnz: Integrated Enzyme entry for 1.1.1.145

• MetaCyc entry for 1.1.1.145

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003854: 3-beta-hydroxy-delta5-steroid dehydrogenase

• AMIGO entry for GO code 0003854: 3-beta-hydroxy-delta5-steroid dehydrogenase