3beta-hydroxy-5alpha-steroid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 3beta-hydroxy-5alpha-steroid dehydrogenase (EC 1.1.1.278) is an enzyme that catalyzes the chemical reaction

3beta-hydroxy-5alpha-pregnane-20-one + NADP⁺ 5alpha-pregnan-3,20-dione + NADPH + H⁺

Thus, the two substrates of this enzyme are 3beta-hydroxy-5alpha-pregnane-20-one and NADP⁺, whereas its 3 products are 5alpha-pregnan-3,20-dione, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase.

[edit] References

• IUBMB entry for 1.1.1.278
• BRENDA references for 1.1.1.278 (Recommended.)
• PubMed references for 1.1.1.278
• PubMed Central references for 1.1.1.278
• Google Scholar references for 1.1.1.278
• Lindemann P and Luckner M (1997). "Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata". Phytochemistry 46: 507–513. doi:10.1016/S0031-9422(97)00315-4. 
• Warneck HM, Seitz HU (1990). "3 beta-hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH". Z. Naturforsch. [C]. 45: 963–72. PMID 2291772. 

[edit] External links

• IUBMB entry for 1.1.1.278

• KEGG entry for 1.1.1.278

• BRENDA entry for 1.1.1.278

• NiceZyme view of 1.1.1.278

• EC2PDB: PDB structures for 1.1.1.278

• PRIAM entry for 1.1.1.278

• PUMA2 entry for 1.1.1.278

• IntEnz: Integrated Enzyme entry for 1.1.1.278

• MetaCyc entry for 1.1.1.278

• Atomic-resolution structures of enzymes belonging to this class