3beta(or 20alpha)-hydroxysteroid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 3beta(or 20alpha)-hydroxysteroid dehydrogenase (EC 1.1.1.210) is an enzyme that catalyzes the chemical reaction

5alpha-androstan-3beta,17beta-diol + NADP⁺ 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H⁺

Thus, the two substrates of this enzyme are 5alpha-androstan-3beta,17beta-diol and NADP⁺, whereas its 3 products are 17beta-hydroxy-5alpha-androstan-3-one, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase. Other names in common use include progesterone reductase, dehydrogenase, 3beta,20alpha-hydroxy steroid, and 3beta,20alpha-hydroxysteroid oxidoreductase.

[edit] References

• IUBMB entry for 1.1.1.210
• BRENDA references for 1.1.1.210 (Recommended.)
• PubMed references for 1.1.1.210
• PubMed Central references for 1.1.1.210
• Google Scholar references for 1.1.1.210
• Sharaf MA, Sweet F (1982). "Dual activity at an enzyme active site: 3 beta,20 alpha-hydroxysteroid oxidoreductase from fetal blood". Biochemistry. 21: 4615–20. doi:10.1021/bi00262a016. PMID 6958329. 

[edit] External links

The CAS registry number for this enzyme class is 82869-26-9.

• IUBMB entry for 1.1.1.210

• KEGG entry for 1.1.1.210

• BRENDA entry for 1.1.1.210

• NiceZyme view of 1.1.1.210

• EC2PDB: PDB structures for 1.1.1.210

• PRIAM entry for 1.1.1.210

• PUMA2 entry for 1.1.1.210

• IntEnz: Integrated Enzyme entry for 1.1.1.210

• MetaCyc entry for 1.1.1.210

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047024: 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase

• AMIGO entry for GO code 0047024: 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase