3Beta Hydroxysteroid dehydrogenase

3 β-Hydroxysteroid dehydrogenase, or 3 β-HSD is a group of steroidogenic enzymes.^[1]

The main steroidogenic isoform, 3 β-HSD I, catalyzes the conversion of pregnenolone to progesterone, the conversion of 17-Hydroxypregnenolone to 17-Hydroxyprogesterone, and the conversion of DHEA to Androstenedione.

It is mainly expressed in the gonads and the adrenal cortex.

[edit] Pathway

Pathway

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^ Payne AH, Abbaszade IG, Clarke TR, Bain PA, Park CH (January 1997). "The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression.". Steroids 62 (1): 169–75. Elsevier. doi:10.1016/S0039-128X(96)00177-8. PMID 9029733.

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1 NAD/NADP acceptor	Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase

1.1.2 cytochrome acceptor	Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553)

1.1.3 oxygen acceptor	Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase

1.1.4 disulfide as acceptor	Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5 quinone/similar acceptor	Quinoprotein glucose dehydrogenase

1.1.99 other acceptors	Choline dehydrogenase