3alpha-hydroxycholanate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-cholanate + NAD⁺ 3-oxo-5beta-cholanate + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-cholanate and NAD⁺, whereas its 3 products are 3-oxo-5beta-cholanate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1IHI.

[edit] References

• IUBMB entry for 1.1.1.52
• BRENDA references for 1.1.1.52 (Recommended.)
• PubMed references for 1.1.1.52
• PubMed Central references for 1.1.1.52
• Google Scholar references for 1.1.1.52
• HAYAISHI O, SATO Y, JAKOBY WB, STOHLMAN EF (1955). "Reversible enzymatic oxidation of bile acids". Arch. Biochem. 56: 554–5. doi:10.1016/0003-9861(55)90278-2. PMID 14377608. 

[edit] External links

The CAS registry number for this enzyme class is 9028-57-3.

• IUBMB entry for 1.1.1.52

• KEGG entry for 1.1.1.52

• BRENDA entry for 1.1.1.52

• NiceZyme view of 1.1.1.52

• EC2PDB: PDB structures for 1.1.1.52

• PRIAM entry for 1.1.1.52

• PUMA2 entry for 1.1.1.52

• IntEnz: Integrated Enzyme entry for 1.1.1.52

• MetaCyc entry for 1.1.1.52

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047043: 3-alpha-hydroxycholanate dehydrogenase

• AMIGO entry for GO code 0047043: 3-alpha-hydroxycholanate dehydrogenase