3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase

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In enzymology, a 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase (EC 1.1.1.152) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-androstane-17-one + NAD⁺ 5beta-androstane-3,17-dione + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-androstane-17-one and NAD⁺, whereas its 3 products are 5beta-androstane-3,17-dione, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase. Other names in common use include etiocholanolone 3alpha-dehydrogenase, etiocholanolone 3alpha-dehydrogenase, and 3alpha-hydroxy-5beta-steroid dehydrogenase. This enzyme participates in androgen and estrogen metabolism.

[edit] References

• IUBMB entry for 1.1.1.152
• BRENDA references for 1.1.1.152 (Recommended.)
• PubMed references for 1.1.1.152
• PubMed Central references for 1.1.1.152
• Google Scholar references for 1.1.1.152
• Roe CR, Kaplan NO (1969). "Purification and substrate specificities of bacterial hydroxysteroid dehydrogenases". Biochemistry. 8: 5093–103. doi:10.1021/bi00840a063. PMID 5365796. 

[edit] External links

The CAS registry number for this enzyme class is 37250-77-4.

• IUBMB entry for 1.1.1.152

• KEGG entry for 1.1.1.152

• BRENDA entry for 1.1.1.152

• NiceZyme view of 1.1.1.152

• EC2PDB: PDB structures for 1.1.1.152

• PRIAM entry for 1.1.1.152

• PUMA2 entry for 1.1.1.152

• IntEnz: Integrated Enzyme entry for 1.1.1.152

• MetaCyc entry for 1.1.1.152

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047009: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase

• AMIGO entry for GO code 0047009: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase