3alpha(S)-strictosidine beta-glucosidase

From Wikipedia, the free encyclopedia

In enzymology, a 3alpha(S)-strictosidine beta-glucosidase (EC 3.2.1.105) is an enzyme that catalyzes the chemical reaction

strictosidine + H₂O D-glucose + strictosidine aglycone

Thus, the two substrates of this enzyme are strictosidine and H₂O, whereas its two products are D-glucose and strictosidine aglycone.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is strictosidine beta-D-glucohydrolase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 3.2.1.105
• BRENDA references for 3.2.1.105 (Recommended.)
• PubMed references for 3.2.1.105
• PubMed Central references for 3.2.1.105
• Google Scholar references for 3.2.1.105
• Hemscheidt T, Zenk MH (1980). "Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures". FEBS. Lett. 110: 187–91. doi:10.1016/0014-5793(80)80069-X. PMID 6768587. 
• Barleben L, Ma X, Koepke J, Peng G, Michel H, Stockigt J (2005). "Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons". Biochim. Biophys. Acta. 1747: 89–92. PMID 15680242. 

[edit] External links

The CAS registry number for this enzyme class is 73379-57-4.

• IUBMB entry for 3.2.1.105

• KEGG entry for 3.2.1.105

• BRENDA entry for 3.2.1.105

• NiceZyme view of 3.2.1.105

• EC2PDB: PDB structures for 3.2.1.105

• PRIAM entry for 3.2.1.105

• PUMA2 entry for 3.2.1.105

• IntEnz: Integrated Enzyme entry for 3.2.1.105

• MetaCyc entry for 3.2.1.105

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050422: strictosidine beta-glucosidase

• AMIGO entry for GO code 0050422: strictosidine beta-glucosidase