3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

From Wikipedia, the free encyclopedia

In enzymology, a 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.239) is an enzyme that catalyzes the chemical reaction

testosterone + NAD⁺ androst-4-ene-3,17-dione + NADH + H⁺

Thus, the two substrates of this enzyme are testosterone and NAD⁺, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase. Other names in common use include 3alpha,17beta-hydroxy steroid dehydrogenase, 3alpha(17beta)-HSD, and 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+). This enzyme participates in androgen and estrogen metabolism.

[edit] References

• IUBMB entry for 1.1.1.239
• BRENDA references for 1.1.1.239 (Recommended.)
• PubMed references for 1.1.1.239
• PubMed Central references for 1.1.1.239
• Google Scholar references for 1.1.1.239
• Ohmura M, Hara A, Nakagawa M, Sawada H (1990). "Demonstration of 3 alpha(17 beta)-hydroxysteroid dehydrogenase distinct from 3 alpha-hydroxysteroid dehydrogenase in hamster liver". Biochem. J. 266: 583–9. PMID 2317205. 

[edit] External links

The CAS registry number for this enzyme class is 126469-82-7.

• IUBMB entry for 1.1.1.239

• KEGG entry for 1.1.1.239

• BRENDA entry for 1.1.1.239

• NiceZyme view of 1.1.1.239

• EC2PDB: PDB structures for 1.1.1.239

• PRIAM entry for 1.1.1.239

• PUMA2 entry for 1.1.1.239

• IntEnz: Integrated Enzyme entry for 1.1.1.239

• MetaCyc entry for 1.1.1.239

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047035: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+)

• AMIGO entry for GO code 0047035: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+)