3-propylmalate synthase

From Wikipedia, the free encyclopedia

In enzymology, a 3-propylmalate synthase (EC 2.3.3.12) is an enzyme that catalyzes the chemical reaction

pentanoyl-CoA + H₂O + glyoxylate 3-propylmalate + CoA

The 3 substrates of this enzyme are pentanoyl-CoA, H₂O, and glyoxylate, whereas its two products are 3-propylmalate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming). Other names in common use include 3-(n-propyl)-malate synthase, 3-propylmalate glyoxylate-lyase (CoA-pentanoylating), beta-n-propylmalate synthase, and n-propylmalate synthase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

[edit] References

• IUBMB entry for 2.3.3.12
• BRENDA references for 2.3.3.12 (Recommended.)
• PubMed references for 2.3.3.12
• PubMed Central references for 2.3.3.12
• Google Scholar references for 2.3.3.12
• IMAI K, REEVES HC, AJL SJ (1963). "N-PROPYLMALATE SYNTHETASE". J. Biol. Chem. 238: 3193–8. PMID 14085361. 

[edit] External links

The CAS registry number for this enzyme class is 37290-62-3.

• IUBMB entry for 2.3.3.12

• KEGG entry for 2.3.3.12

• BRENDA entry for 2.3.3.12

• NiceZyme view of 2.3.3.12

• EC2PDB: PDB structures for 2.3.3.12

• PRIAM entry for 2.3.3.12

• PUMA2 entry for 2.3.3.12

• IntEnz: Integrated Enzyme entry for 2.3.3.12

• MetaCyc entry for 2.3.3.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050442: 3-propylmalate synthase

• AMIGO entry for GO code 0050442: 3-propylmalate synthase