3-phytase

From Wikipedia, the free encyclopedia

In enzymology, a 3-phytase (EC 3.1.3.8) is an enzyme that catalyzes the chemical reaction

myo-inositol hexakisphosphate + H₂O $\rightleftharpoons$ 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate

Thus, the two substrates of this enzyme are myo-inositol hexakisphosphate and H₂O, whereas its two products are 1D-myo-inositol 1,2,4,5,6-pentakisphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-hexakisphosphate 3-phosphohydrolase. Other names in common use include 1-phytase, phytase, phytate 1-phosphatase, and phytate 6-phosphatase. This enzyme participates in inositol phosphate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1CVM, 1IHP, 1POO, 1QFX, 1QLG, 1QWO, 1SK8, 1SK9, 1SKA, 1SKB, 2GFI, and 2POO.

[edit] References

IUBMB entry for 3.1.3.8
BRENDA references for 3.1.3.8 (Recommended.)
PubMed references for 3.1.3.8
PubMed Central references for 3.1.3.8
Google Scholar references for 3.1.3.8
Cosgrove DJ (1969). "Ion-exchange chromatography of inositol polyphosphates". Ann. N. Y. Acad. Sci. 165: 677–86. PMID 4310381.
Johnson LF, Tate ME (1969). "The structure of myo-inositol pentaphosphates". Ann. N. Y. Acad. Sci. 165: 526–32. PMID 4310376.
Irving GC, Cosgrove DJ (1972). "Inositol phosphate phosphatases of microbiological origin: the inositol pentaphosphate products of Aspergillus ficuum phytases". J. Bacteriol. 112: 434–8. PMID 4342816.
Cosgrove DJ. "Inositol Phosphates: Their Chemistry, Biochemistry, and Physiology, Elsevier, Amsterdam, 1980".