3-phosphoshikimate 1-carboxyvinyltransferase

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In enzymology, a 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + 3-phosphoshikimate \rightleftharpoons phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate

Thus, the two substrates of this enzyme are phosphoenolpyruvate and 3-phosphoshikimate, whereas its two products are phosphate and 5-O-(1-carboxyvinyl)-3-phosphoshikimate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase. Other names in common use include 5-enolpyruvylshikimate-3-phosphate synthase, 3-enolpyruvylshikimate 5-phosphate synthase, 3-enolpyruvylshikimic acid-5-phosphate synthetase, 5'-enolpyruvylshikimate-3-phosphate synthase, 5-enolpyruvyl-3-phosphoshikimate synthase, 5-enolpyruvylshikimate-3-phosphate synthetase, 5-enolpyruvylshikimate-3-phosphoric acid synthase, enolpyruvylshikimate phosphate synthase, and EPSP synthase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. At least one compound, Glyphosate is known to inhibit this enzyme.

Contents

[edit] Structural studies

As of late 2007, 22 structures have been solved for this class of enzymes, with PDB accession codes 1G6S, 1G6T, 1MI4, 1P88, 1P89, 1Q36, 1RF4, 1RF5, 1RF6, 1X8R, 1X8T, 2AA9, 2AAY, 2BJB, 2GG4, 2GG6, 2GGA, 2GGD, 2QFQ, 2QFS, 2QFT, and 2QFU.

[edit] References

[edit] External links

The CAS registry number for this enzyme class is 9068-73-9.

[edit] Gene Ontology (GO) codes

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