3-mercaptopyruvate sulfurtransferase

From Wikipedia, the free encyclopedia

In enzymology, a 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) is an enzyme that catalyzes the chemical reaction

3-mercaptopyruvate + cyanide $\rightleftharpoons$ pyruvate + thiocyanate

Thus, the two substrates of this enzyme are 3-mercaptopyruvate and cyanide, whereas its two products are pyruvate and thiocyanate.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3-mercaptopyruvate:cyanide sulfurtransferase. This enzyme is also called beta-mercaptopyruvate sulfurtransferase. This enzyme participates in cysteine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1OKG and 1URH.

[edit] References

IUBMB entry for 2.8.1.2
BRENDA references for 2.8.1.2 (Recommended.)
PubMed references for 2.8.1.2
PubMed Central references for 2.8.1.2
Google Scholar references for 2.8.1.2
Fiedler H and Wood JL (1956). "Specificity studies on the beta-mercaptopyruvate-cyanide transsulfuration system". J. Biol. Chem. 222: 387–397.
HYLIN JW, WOOD JL (1959). "Enzymatic formation of polysulfides from mercaptopyruvate". J. Biol. Chem. 234: 2141–4. PMID 13673028.
Sorbo BH (1957). "Enzymic transfer of sulfur from mercaptopyruvate to sulfite or sulfinates". Biochem. Biophys. Acta 24: 324–329. doi:10.1016/0006-3002(57)90201-9.
Vachek H, Wood JL (1972). "Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli". Biochim. Biophys. Acta. 258: 133–46. PMID 4550801.
Van den Hamer CJ, Morell AG, Scheinberg IH (1967). "A study of the cooper content of beta-mercaptopyruvate trans-sulfurase". J. Biol. Chem. 242: 2514–6. PMID 6026243.