3-hydroxypropionate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction

3-hydroxypropanoate + NAD⁺ 3-oxopropanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 3-hydroxypropanoate and NAD⁺, whereas its 3 products are 3-oxopropanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxypropanoate:NAD+ oxidoreductase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.

[edit] References

• IUBMB entry for 1.1.1.59
• BRENDA references for 1.1.1.59 (Recommended.)
• PubMed references for 1.1.1.59
• PubMed Central references for 1.1.1.59
• Google Scholar references for 1.1.1.59
• Den H, Robinson WG and Coon MJ (1959). "Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde". J. Biol. Chem. 234: 1666–1671. 

[edit] External links

The CAS registry number for this enzyme class is 9028-59-5.

• IUBMB entry for 1.1.1.59

• KEGG entry for 1.1.1.59

• BRENDA entry for 1.1.1.59

• NiceZyme view of 1.1.1.59

• EC2PDB: PDB structures for 1.1.1.59

• PRIAM entry for 1.1.1.59

• PUMA2 entry for 1.1.1.59

• IntEnz: Integrated Enzyme entry for 1.1.1.59

• MetaCyc entry for 1.1.1.59

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047565: 3-hydroxypropionate dehydrogenase

• AMIGO entry for GO code 0047565: 3-hydroxypropionate dehydrogenase