3-hydroxypimeloyl-CoA dehydrogenase
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In enzymology, a 3-hydroxypimeloyl-CoA dehydrogenase (EC 1.1.1.259) is an enzyme that catalyzes the chemical reaction
- 3-hydroxypimeloyl-CoA + NAD+ 3-oxopimeloyl-CoA + NADH + H+
Thus, the two substrates of this enzyme are 3-hydroxypimeloyl-CoA and NAD+, whereas its 3 products are 3-oxopimeloyl-CoA, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxypimeloyl-CoA:NAD+ oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.
[edit] References
- IUBMB entry for 1.1.1.259
- BRENDA references for 1.1.1.259 (Recommended.)
- PubMed references for 1.1.1.259
- PubMed Central references for 1.1.1.259
- Google Scholar references for 1.1.1.259
- Harwood CS, Gibson J (1997). "Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?". J. Bacteriol. 179: 301–9. PMID 8990279.