3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase

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In enzymology, a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hexadec-2-enoyl-[acyl-carrier-protein] + H₂O

Hence, this enzyme has one substrate, [[(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein]]], and two products, [[hexadec-2-enoyl-[acyl-carrier-protein]]] and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase (hexadec-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, beta-hydroxypalmitoyl-acyl carrier protein dehydrase, beta-hydroxypalmitoyl thioester dehydratase, beta-hydroxypalmityl-ACP dehydrase, and (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase. This enzyme participates in fatty acid biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PFF.

[edit] References

• IUBMB entry for 4.2.1.61
• BRENDA references for 4.2.1.61 (Recommended.)
• PubMed references for 4.2.1.61
• PubMed Central references for 4.2.1.61
• Google Scholar references for 4.2.1.61
• Mizugaki M, Swindell AC, Wakil SJ (1968). "Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E coli fatty acid synthetase". Biochem. Biophys. Res. Commun. 33: 520–7. doi:10.1016/0006-291X(68)90607-4. PMID 4881058. 

[edit] External links

The CAS registry number for this enzyme class is 9030-86-8.

• IUBMB entry for 4.2.1.61

• KEGG entry for 4.2.1.61

• BRENDA entry for 4.2.1.61

• NiceZyme view of 4.2.1.61

• EC2PDB: PDB structures for 4.2.1.61

• PRIAM entry for 4.2.1.61

• PUMA2 entry for 4.2.1.61

• IntEnz: Integrated Enzyme entry for 4.2.1.61

• MetaCyc entry for 4.2.1.61

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004317: 3-hydroxypalmitoyl-[acyl-carrier-protein dehydratase]

• AMIGO entry for GO code 0004317: 3-hydroxypalmitoyl-[acyl-carrier-protein dehydratase]