3-hydroxyoctanoyl-(acyl-carrier-protein) dehydratase

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In enzymology, a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] oct-2-enoyl-[acyl-carrier-protein] + H₂O

Hence, this enzyme has one substrate, [[(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein]]], and two products, [[oct-2-enoyl-[acyl-carrier-protein]]] and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase, D-3-hydroxyoctanoyl-acyl carrier protein dehydratase, beta-hydroxyoctanoyl-acyl carrier protein dehydrase, beta-hydroxyoctanoyl thioester dehydratase, beta-hydroxyoctanoyl-ACP-dehydrase, and (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase.

[edit] References

• IUBMB entry for 4.2.1.59
• BRENDA references for 4.2.1.59 (Recommended.)
• PubMed references for 4.2.1.59
• PubMed Central references for 4.2.1.59
• Google Scholar references for 4.2.1.59
• Mizugaki M, Swindell AC, Wakil SJ (1968). "Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E coli fatty acid synthetase". Biochem. Biophys. Res. Commun. 33: 520–7. doi:10.1016/0006-291X(68)90607-4. PMID 4881058. 

[edit] External links

The CAS registry number for this enzyme class is 9030-85-7.

• IUBMB entry for 4.2.1.59

• KEGG entry for 4.2.1.59

• BRENDA entry for 4.2.1.59

• NiceZyme view of 4.2.1.59

• EC2PDB: PDB structures for 4.2.1.59

• PRIAM entry for 4.2.1.59

• PUMA2 entry for 4.2.1.59

• IntEnz: Integrated Enzyme entry for 4.2.1.59

• MetaCyc entry for 4.2.1.59

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047451: 3-hydroxyoctanoyl-[acyl-carrier-protein dehydratase]

• AMIGO entry for GO code 0047451: 3-hydroxyoctanoyl-[acyl-carrier-protein dehydratase]