3-hydroxymethylcephem carbamoyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxymethylcephem carbamoyltransferase (EC 2.1.3.7) is an enzyme that catalyzes the chemical reaction

carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate phosphate + a 3-carbamoyloxymethylcephem

Thus, the two substrates of this enzyme are carbamoyl phosphate and 3-hydroxymethylceph-3-em-4-carboxylate, whereas its two products are phosphate and 3-carbamoyloxymethylcephem.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase. This enzyme has at least one effector, ATP.

[edit] References

• IUBMB entry for 2.1.3.7
• BRENDA references for 2.1.3.7 (Recommended.)
• PubMed references for 2.1.3.7
• PubMed Central references for 2.1.3.7
• Google Scholar references for 2.1.3.7
• Brewer SJ, Taylor PM, Turner MK (1980). "An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus". Biochem. J. 185: 555–64. PMID 6248024. 

[edit] External links

The CAS registry number for this enzyme class is 74315-96-1.

• IUBMB entry for 2.1.3.7

• KEGG entry for 2.1.3.7

• BRENDA entry for 2.1.3.7

• NiceZyme view of 2.1.3.7

• EC2PDB: PDB structures for 2.1.3.7

• PRIAM entry for 2.1.3.7

• PUMA2 entry for 2.1.3.7

• IntEnz: Integrated Enzyme entry for 2.1.3.7

• MetaCyc entry for 2.1.3.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047155: 3-hydroxymethylcephem carbamoyltransferase

• AMIGO entry for GO code 0047155: 3-hydroxymethylcephem carbamoyltransferase