3-hydroxyisobutyryl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methylpropanoyl-CoA + H₂O CoA + 3-hydroxy-2-methylpropanoate

Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoyl-CoA and H₂O, whereas its two products are CoA and 3-hydroxy-2-methylpropanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism.

[edit] References

• IUBMB entry for 3.1.2.4
• BRENDA references for 3.1.2.4 (Recommended.)
• PubMed references for 3.1.2.4
• PubMed Central references for 3.1.2.4
• Google Scholar references for 3.1.2.4
• Rendina G and Coon MJ (1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids". J. Biol. Chem. 225: 523–534. 

[edit] External links

The CAS registry number for this enzyme class is 9025-88-1.

• IUBMB entry for 3.1.2.4

• KEGG entry for 3.1.2.4

• BRENDA entry for 3.1.2.4

• NiceZyme view of 3.1.2.4

• EC2PDB: PDB structures for 3.1.2.4

• PRIAM entry for 3.1.2.4

• PUMA2 entry for 3.1.2.4

• IntEnz: Integrated Enzyme entry for 3.1.2.4

• MetaCyc entry for 3.1.2.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003860: 3-hydroxyisobutyryl-CoA hydrolase

• AMIGO entry for GO code 0003860: 3-hydroxyisobutyryl-CoA hydrolase