3-hydroxybutyrate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxybutanoate + NAD⁺ acetoacetate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD⁺, whereas its 3 products are acetoacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD+ oxidoreductase. Other names in common use include NAD+-beta-hydroxybutyrate dehydrogenase, hydroxybutyrate oxidoreductase, beta-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, 3-D-hydroxybutyrate dehydrogenase, and beta-hydroxybutyric dehydrogenase. This enzyme participates in synthesis and degradation of ketone bodies and butanoate metabolism.

Contents 1 Structural studies 2 See also 3 References 4 External links 4.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WMB and 1X1T.

[edit] See also

• BDH1

[edit] References

• IUBMB entry for 1.1.1.30
• BRENDA references for 1.1.1.30 (Recommended.)
• PubMed references for 1.1.1.30
• PubMed Central references for 1.1.1.30
• Google Scholar references for 1.1.1.30
• Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH (1967). "Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides". Biochem. J. 102: 423–31. PMID 4291491. 
• Delafield FP, Cooksey KE, Doudoroff M (1965). "beta-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei". J. Biol. Chem. 240: 4023–8. PMID 4954074. 
• Lehninger AL, Sudduth HC and Wise JB (1960). "D-beta-Hydroxybutyric dehydrogenase of mitochondria". J. Biol. Chem. 235: 2450–2455. 

[edit] External links

The CAS registry number for this enzyme class is 9028-38-0.

• IUBMB entry for 1.1.1.30

• KEGG entry for 1.1.1.30

• BRENDA entry for 1.1.1.30

• NiceZyme view of 1.1.1.30

• EC2PDB: PDB structures for 1.1.1.30

• PRIAM entry for 1.1.1.30

• PUMA2 entry for 1.1.1.30

• IntEnz: Integrated Enzyme entry for 1.1.1.30

• MetaCyc entry for 1.1.1.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003858: 3-hydroxybutyrate dehydrogenase

• AMIGO entry for GO code 0003858: 3-hydroxybutyrate dehydrogenase