3-hydroxyanthranilate oxidase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxyanthranilate oxidase (EC 1.10.3.5) is an enzyme that catalyzes the chemical reaction

3-hydroxyanthranilate + O₂ 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H₂O₂

Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O₂, whereas its two products are 6-imino-5-oxocyclohexa-1,3-dienecarboxylate and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with oxygen as acceptor. The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen oxidoreductase. This enzyme is also called 3-hydroxyanthranilic acid oxidase.

[edit] References

• IUBMB entry for 1.10.3.5
• BRENDA references for 1.10.3.5 (Recommended.)
• PubMed references for 1.10.3.5
• PubMed Central references for 1.10.3.5
• Google Scholar references for 1.10.3.5
• MORGAN LR Jr, WEIMORTS DM, AUBERT CC (1965). "OXIDATION OF 3-HYDROXYANTHRANILIC ACID BY A SOLUBLE LIVER FRACTION FROM POIKILOTHERMIC VERTEBRATES". Biochim. Biophys. Acta. 100: 393–402. PMID 14347936. 

[edit] External links

The CAS registry number for this enzyme class is 37256-53-4.

• IUBMB entry for 1.10.3.5

• KEGG entry for 1.10.3.5

• BRENDA entry for 1.10.3.5

• NiceZyme view of 1.10.3.5

• EC2PDB: PDB structures for 1.10.3.5

• PRIAM entry for 1.10.3.5

• PUMA2 entry for 1.10.3.5

• IntEnz: Integrated Enzyme entry for 1.10.3.5

• MetaCyc entry for 1.10.3.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047561: 3-hydroxyanthranilate oxidase

• AMIGO entry for GO code 0047561: 3-hydroxyanthranilate oxidase

v • d • e Metabolism: amino acid metabolism - synthesis and catabolism enzymes (essential in CAPS) K→acetyl-CoA LYSINE→ Saccharopine dehydrogenase - Glutaryl-CoA dehydrogenase LEUCINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase - Methylglutaconyl-CoA hydratase - 3-hydroxy-3-methylglutaryl-CoA lyase TRYPTOPHAN→ Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase - Arylformamidase - Kynureninase - 3-hydroxyanthranilate oxidase - Aminocarboxymuconate-semialdehyde decarboxylase - Aminomuconate-semialdehyde dehydrogenase PHENYLALANINE→tyrosine→ (see below) G→pyruvate glycine→serine→ Serine hydroxymethyltransferase - Serine dehydratase alanine→ Alanine transaminase cysteine→ D-cysteine desulfhydrase threonine→ L-threonine dehydrogenase G→glutamate HISTIDINE→ Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase proline→ Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1 arginine→ Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase →alpha-ketoglutarate→TCA Glutamate dehydrogenase G→propionyl-CoA VALINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Enoyl-CoA hydratase - 3-hydroxyisobutyryl-CoA hydrolase - 3-hydroxyisobutyrate dehydrogenase - Methylmalonate semialdehyde dehydrogenase ISOLEUCINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - 3-hydroxy-2-methylbutyryl-CoA dehydrogenase METHIONINE→ Methionine adenosyltransferase - Adenosylhomocysteinase - Cystathionine beta synthase - Cystathionine gamma-lyase (methionine synthesis: MTR/Homocysteine methyltransferase) THREONINE→ Threonine aldolase →succinyl-CoA→TCA Propionyl-CoA carboxylase - Methylmalonyl-CoA mutase G→fumarate PHENYLALANINE→tyrosine→ Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase G→oxaloacetate asparagine→aspartate→ Asparaginase/Asparagine synthetase - Aspartate transaminase Other tyrosine→melanin Tyrosinase cysteine+glutamate→glutathione Gamma-glutamylcysteine synthetase - Glutathione synthetase - Gamma-glutamyl transpeptidase glycine→creatine Guanidinoacetate N-methyltransferase - Creatine kinase glutamate→glutamine Glutamine synthetase - Glutaminase proline+lysine→collagen Prolyl hydroxylase - Lysyl hydroxylase see also disorders, intermediates