3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (EC 2.4.1.65) is an enzyme that catalyzes the chemical reaction

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R $\rightleftharpoons$ GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and [[beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R]], whereas its 3 products are GDP, [[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-]], and glucosaminyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase. Other names in common use include (Lea)-dependent (alpha-3/4)-fucosyltransferase, alpha(1,3/1,4) fucosyltransferase III, alpha-(1->4)-L-fucosyltransferase, alpha-4-L-fucosyltransferase, beta-acetylglucosaminylsaccharide fucosyltransferase, FucT-II, Lewis alpha-(1->3/4)-fucosyltransferase, Lewis blood group alpha-(1->3/4)-fucosyltransferase, Lewis(Le) blood group gene-dependent, alpha-(1->3/4)-L-fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, blood-group substance Lea-dependent fucosyltransferase, guanosine diphosphofucose-beta-acetylglucosaminylsaccharide, 4-alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase, 3-alpha-galactosyl-N-acetylglucosaminide, 4-alpha-L-fucosyltransferase, GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and 4I-alpha-L-fucosyltransferase. This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.

[edit] References

IUBMB entry for 2.4.1.65
BRENDA references for 2.4.1.65 (Recommended.)
PubMed references for 2.4.1.65
PubMed Central references for 2.4.1.65
Google Scholar references for 2.4.1.65
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Rasko DA, Wang G, Palcic MM, Taylor DE (2000). "Cloning and characterization of the alpha(1,3/4) fucosyltransferase of Helicobacter pylori". J. Biol. Chem. 275: 4988–94. doi:10.1074/jbc.275.7.4988. PMID 10671538.
Wilson IB (2001). "Identification of a cDNA encoding a plant Lewis-type alpha1,4-fucosyltransferase". Glycoconj. J. 18: 439–47. doi:10.1023/A:1016030000527. PMID 12084979.
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE (2003). "C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer". J. Biol. Chem. 278: 21893–900. doi:10.1074/jbc.M301704200. PMID 12676935.