3-deoxyoctulosonase

From Wikipedia, the free encyclopedia

In enzymology, a 3-deoxyoctulosonase (EC 3.2.1.144) is an enzyme that catalyzes the chemical reaction

3-deoxyoctulosonyl-lipopolysaccharide + H₂O 3-deoxyoctulosonic acid + lipopolysaccharide

Thus, the two substrates of this enzyme are 3-deoxyoctulosonyl-lipopolysaccharide and H₂O, whereas its two products are 3-deoxyoctulosonic acid and lipopolysaccharide.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 3-deoxyoctulosonyl-lipopolysaccharide hydrolase. This enzyme is also called alpha-Kdo-ase.

[edit] References

• IUBMB entry for 3.2.1.144
• BRENDA references for 3.2.1.144 (Recommended.)
• PubMed references for 3.2.1.144
• PubMed Central references for 3.2.1.144
• Google Scholar references for 3.2.1.144
• Li YT, Wang LX, Pavlova NV, Li SC, Lee YC (1997). "alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid". J. Biol. Chem. 272: 26419–24. doi:10.1074/jbc.272.42.26419. PMID 9334217. 

[edit] External links

• IUBMB entry for 3.2.1.144

• KEGG entry for 3.2.1.144

• BRENDA entry for 3.2.1.144

• NiceZyme view of 3.2.1.144

• EC2PDB: PDB structures for 3.2.1.144

• PRIAM entry for 3.2.1.144

• PUMA2 entry for 3.2.1.144

• IntEnz: Integrated Enzyme entry for 3.2.1.144

• MetaCyc entry for 3.2.1.144

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050534: 3-deoxyoctulosonase

• AMIGO entry for GO code 0050534: 3-deoxyoctulosonase