3-demethylubiquinone-9 3-O-methyltransferase

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In enzymology, a 3-demethylubiquinone-9 3-O-methyltransferase (EC 2.1.1.64) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3-demethylubiquinone-9 $\rightleftharpoons$ S-adenosyl-L-homocysteine + ubiquinone-9

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-demethylubiquinone-9, whereas its two products are S-adenosylhomocysteine and ubiquinone-9.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1, 4-benzoquinone 3-O-methyltransferase. Other names in common use include 5-demethylubiquinone-9 methyltransferase, OMHMB-methyltransferase, 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone, methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-, and 1,4-benzoquinone-O-methyltransferase. This enzyme participates in ubiquinone biosynthesis.

[edit] References

IUBMB entry for 2.1.1.64
BRENDA references for 2.1.1.64 (Recommended.)
PubMed references for 2.1.1.64
PubMed Central references for 2.1.1.64
Google Scholar references for 2.1.1.64
Houser RM, Olson RE (1977). "5-demethylubiquinone-9-methyltransferase from rat liver mitochondria. Characterization, localization, and solubilization". J. Biol. Chem. 252: 4017–21. PMID 863914.
Leppik RA, Stroobant P, Shineberg B, Young IG, Gibson F (1976). "Membrane-associated reactions in ubiquinone biosynthesis 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase". Biochim. Biophys. Acta. 428: 146–56. PMID 769831.