3-dehydrosphinganine reductase

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In enzymology, a 3-dehydrosphinganine reductase (EC 1.1.1.102) is an enzyme that catalyzes the chemical reaction

sphinganine + NADP⁺ $\rightleftharpoons$ 3-dehydrosphinganine + NADPH + H⁺

Thus, the two substrates of this enzyme are sphinganine and NADP⁺, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase. Other names in common use include D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, DSR, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, and D-3-oxosphinganine:B-NADPH oxidoreductase. This enzyme participates in sphingolipid metabolism.

[edit] References

IUBMB entry for 1.1.1.102
BRENDA references for 1.1.1.102 (Recommended.)
PubMed references for 1.1.1.102
PubMed Central references for 1.1.1.102
Google Scholar references for 1.1.1.102
Stoffel W, LeKim D, Sticht G (1968). "Biosynthesis of dihydrosphingosine in vitro". Hoppe. Seylers. Z. Physiol. Chem. 349: 664–70. PMID 4386961.
Stoffel W, LeKim D, Sticht G (1968). "Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one)". Hoppe. Seylers. Z. Physiol. Chem. 349: 1637–44. PMID 4387676.