3-(imidazol-5-yl)lactate dehydrogenase

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In enzymology, a 3-(imidazol-5-yl)lactate dehydrogenase (EC 1.1.1.111) is an enzyme that catalyzes the chemical reaction

(S)-3-(imidazol-5-yl)lactate + NAD(P)+ $\rightleftharpoons$ 3-(imidazol-5-yl)pyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-3-(imidazol-5-yl)lactate, NAD⁺, and NADP⁺, whereas its 4 products are 3-(imidazol-5-yl)pyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase. This enzyme is also called imidazol-5-yl lactate dehydrogenase.

[edit] References

IUBMB entry for 1.1.1.111
BRENDA references for 1.1.1.111 (Recommended.)
PubMed references for 1.1.1.111
PubMed Central references for 1.1.1.111
Google Scholar references for 1.1.1.111
Coote JG, Hassall H (1969). "The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by Pseudomonas acidovorans". Biochem. J. 111: 237–9. PMID 4303364.
Cortese R, Brevet J, Hedegaard J, Roche J (1968). "[Identification and purification of an alpha-ketoacid aromatic reductase of Escherichia coli B]". C. R. Seances. Soc. Biol. Fil. 162: 390–5. PMID 4237631.