3,4-dihydroxyphenylacetate 2,3-dioxygenase

From Wikipedia, the free encyclopedia

In enzymology, a 3,4-dihydroxyphenylacetate 2,3-dioxygenase (EC 1.13.11.15) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxyphenylacetate + O₂ 2-hydroxy-5-carboxymethylmuconate semialdehyde

Thus, the two substrates of this enzyme are 3,4-dihydroxyphenylacetate and O₂, whereas its product is 2-hydroxy-5-carboxymethylmuconate semialdehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include 3,4-dihydroxyphenylacetic acid 2,3-dioxygenase, HPC dioxygenase, and homoprotocatechuate 2,3-dioxygenase. This enzyme participates in tyrosine metabolism. It employs one cofactor, iron.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1F1R, 1F1U, 1F1V, 1F1X, 1Q0C, 1Q0O, 2IG9, and 2IGA.

[edit] References

• IUBMB entry for 1.13.11.15
• BRENDA references for 1.13.11.15 (Recommended.)
• PubMed references for 1.13.11.15
• PubMed Central references for 1.13.11.15
• Google Scholar references for 1.13.11.15
• ADACHI K, TAKEDA Y, SENOH S, KITA H (1964). "METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS". Biochim. Biophys. Acta. 93: 483–93. PMID 14263147. 
• Barbour MG, Bayly RC (1981). "Control of meta-cleavage degradation of 4-hydroxyphenylacetate in Pseudomonas putida". J. Bacteriol. 147: 844–50. PMID 6895079. 
• Kutty RK, Devi NA, Veeraswamy M, Ramesh S, Rao PV (1977). "Degradation of (+/-)-synephrine by Arthrobacter synephrinum Oxidation of 3,4-dihydroxyphenylacetate to 2-hydroxy-5-carboxymethyl-muconate semialdehyde". Biochem. J. 167: 163–70. PMID 588248. 

[edit] External links

The CAS registry number for this enzyme class is 37256-56-7.

• IUBMB entry for 1.13.11.15

• KEGG entry for 1.13.11.15

• BRENDA entry for 1.13.11.15

• NiceZyme view of 1.13.11.15

• EC2PDB: PDB structures for 1.13.11.15

• PRIAM entry for 1.13.11.15

• PUMA2 entry for 1.13.11.15

• IntEnz: Integrated Enzyme entry for 1.13.11.15

• MetaCyc entry for 1.13.11.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008687: 3,4-dihydroxyphenylacetate 2,3-dioxygenase

• AMIGO entry for GO code 0008687: 3,4-dihydroxyphenylacetate 2,3-dioxygenase