2C-T-7

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2C-T-7


IUPAC name	2-[2,5-Dimethoxy-4-(propylthio)phenyl]ethanamine
Other names	2,5-Dimethoxy-4-n-propylthiophenethylamine
Identifiers
CAS number	[207740-26-9]
SMILES	NCCC1=C(OC)C=C(SCCC)C(OC)=C1
Properties
Molecular formula	C₁₃H₂₁NO₂S
Molar mass	255.38 g/mol
Melting point	140-150 °C at 33.4 Pa
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

2C-T-7 is a hallucinogenic phenethylamine of the 2C family. In his book PiHKAL (Phenethylamines i Have Known And Loved), Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entheogenic effects that last 8 to 15 hours.^[1] Up until Operation Web Tryp and multiple reported deaths, 2C-T-7 was sold commercially in Dutch smartshops and online as "Blue Mystic".

There has been little real research done on this chemical other than Shulgin's comments in PiHKAL. There have been a few small animal studies mostly aimed at detecting metabolites, and an informal amateur research paper written by an interested party called Sulfurous Samadhi.^[2]

1 Pharmacology
2 Effects
3 Deaths
4 Legality
5 Notes
6 See also
7 External links

[edit] Pharmacology

The mechanism that produces the hallucinogenic and entheogenic effects of 2C-T-7 is most likely to result from action as a 5-HT_2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines.^[3]

As the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase-A inhibitor, 2C-T-7 may likewise have MAO-A inhibitory effects. This could indicate 2C-T-7 is more likely to induce serotonin syndrome than other serotonergic hallucinogens, as at high doses it may slow the degradation of serotonin, a potentially life-threatening condition.^[4]

Several of the deaths involving 2C-T-7 followed co-administration of the drug with stimulants such as MDMA and ephedrine.^{[citation needed]}

[edit] Effects

2C-T-7 Microdot

2C-T-7 is hallucinogenic. In PiHKAL, Shulgin writes that the hallucinations are unique. He also comments on the tenseness of his muscles and his change in voice tone, which lasted some days. Erowid gives the following effects list:

[edit] Positive

sense of well-being (enhanced lucidity, sense of inner peace)
emotional opening
significant closed and open eye visuals
increased appreciation of music

[edit] Neutral

general change in consciousness (as with most psychoactives)
pupil dilation
change in perception of time
visual hallucinations
auditory hallucinations

[edit] Negative

nausea and vomiting
muscle tension
irritating body load
muscle tremors and/or convulsions
memory loss (at higher doses)
delirium (at higher doses) (potentially dangerous)
violent behaviour (at higher doses)

The drug can be taken orally or snorted, although nasal administration is extremely painful.^[5] Use of 2C-T-7 as a nootropic at low doses of 1-10mg has been reported, and it may be useful for this purpose in a similar manner to LSD, which shows modest stimulant and nootropic effects at doses of 10 µg.

[edit] Deaths

The Partnership for a Drug-Free America reports that 2C-T-7 can be lethal even in small doses,^[6]. There have been at least three reported deaths related to 2C-T-7 use, mainly at insufflated doses of 30mg or more or combined with stimulants such as MDMA, as well as a number of very bad trips and hospitalizations, these mostly followed insufflation of 2C-T-7^{[citation needed]}. In January of 2002, Rolling Stone published an article about 2C-T-7 entitled "The New (legal) Killer Drug", although the legal status of the drug was misrepresented in the article. It can cause nausea and, as with many other drugs, may be dangerous when combined with alcohol and/or stimulants.

[edit] Legality

Around the year 2000, 2C-T-7 began to change from an obscure chemical to a drug used at parties and clubs in North America and Europe as it became available through a number of grey-market commercial vendors. This aroused the attention of the authorities, and since many countries have scheduled the chemical.

[edit] Australia

In Australia, 2C-T-2 and 2C-T-7 are covered by the country's comparatively strict analogue drug laws.

[edit] Canada

2C-T-7 is unscheduled in Canada.

[edit] The Netherlands

The Netherlands was the first country in the world to ban 2C-T-7, after being sold in smartshops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market, but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.

[edit] Sweden

2C-T-2 became commercially available in Sweden in the summer of 1998, being sold in smartshops similar to those in the Netherlands. On April 1, 1999, both 2C-T-2 and 2C-T-7, along with MBDB, BDB, 2C-B and PMMA, were banned in Sweden. This was not done by appending these drugs to the country's normal drug laws, but by passing a new law, "Förordning (1999:58) om förbud mot vissa hälsofarliga varor," which banned the drugs as being materials dangerous to health.

[edit] UK

In 1999, Alexander Shulgin was sent a copy of a letter from the British Home Office to several of its administrative associates which in effect placed all compounds listed in PiHKAL into Class A, Britain's equivalent of Schedule I.

[edit] US

On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a Final Rule in the Federal Register permanently placing 2C-T-7 in Schedule I. (69 FR 12794).^[7]^[8]

[edit] Notes

^ Alexander Shulgin. PIHKAL #43.
^ Sulfurous Samadhi
^ Fantegrossi, WE; Harrington AW, Eckler JR, Arshad S, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH (September 2005). "Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats.". Psychopharmacology (Berlin) 181 (3): 496-503.
^ Gallardo-Godoy, A; Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE. (April 7, 2005). "Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.". Journal of Medicinal Chemistry 48 (7): 2407-19.
^ East Bay Express (01-02-07). 2C-T-7's Bad Trip.
^ Partnership for a Drug-Free America. 2C-B, 2C-T-7. Retrieved on 2006-10-04.
^ DEA. Micgrogram Bulletin Jan 2004.
^ U.S. Department of Justice. 2C-T-7 Fast Facts.

[edit] See also

[edit] External links

v • d • e 2Cs

Halogenated	2C-B • 2C-C • 2C-F • 2C-I

Alkylated	2C-D • 2C-E • 2C-P • 2C-G

Alkoxylated	2C-O • 2C-O-4

Alkylthiolated	2C-T • 2C-T-2 • 2C-T-4 • 2C-T-7 • 2C-T-8 • 2C-T-9 • 2C-T-13 • 2C-T-15 • 2C-T-17 • 2C-T-21

Other	2C-H • 2C-N • 2C-SE • 2C-TFM