2'-hydroxyisoflavone reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2'-hydroxyisoflavone reductase (EC 1.3.1.45) is an enzyme that catalyzes the chemical reaction

vestitone + NADP⁺ 2'-hydroxyformononetin + NADPH + H⁺

Thus, the two substrates of this enzyme are vestitone and NADP⁺, whereas its 3 products are 2'-hydroxyformononetin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is vestitone:NADP+ oxidoreductase. Other names in common use include NADPH:2'-hydroxyisoflavone oxidoreductase, isoflavone reductase, and 2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase.

[edit] References

• IUBMB entry for 1.3.1.45
• BRENDA references for 1.3.1.45 (Recommended.)
• PubMed references for 1.3.1.45
• PubMed Central references for 1.3.1.45
• Google Scholar references for 1.3.1.45
• Tiemann K, Hinderer W and Barz W (1987). "Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum". FEBS Lett. 213: 324–328. doi:10.1016/0014-5793(87)81515-6. 

[edit] External links

The CAS registry number for this enzyme class is 128449-69-4.

• IUBMB entry for 1.3.1.45

• KEGG entry for 1.3.1.45

• BRENDA entry for 1.3.1.45

• NiceZyme view of 1.3.1.45

• EC2PDB: PDB structures for 1.3.1.45

• PRIAM entry for 1.3.1.45

• PUMA2 entry for 1.3.1.45

• IntEnz: Integrated Enzyme entry for 1.3.1.45

• MetaCyc entry for 1.3.1.45

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047526: 2'-hydroxyisoflavone reductase

• AMIGO entry for GO code 0047526: 2'-hydroxyisoflavone reductase