2'-hydroxybiphenyl-2-sulfinate desulfinase

From Wikipedia, the free encyclopedia

In enzymology, a 2'-hydroxybiphenyl-2-sulfinate desulfinase (EC 3.13.1.3) is an enzyme that catalyzes the chemical reaction

2'-hydroxybiphenyl-2-sulfinate + H₂O $\rightleftharpoons$ 2-hydroxybiphenyl + sulfite

Thus, the two substrates of this enzyme are 2'-hydroxybiphenyl-2-sulfinate and H₂O, whereas its two products are 2-hydroxybiphenyl and sulfite.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-sulfur bonds. The systematic name of this enzyme class is 2'-hydroxybiphenyl-2-sulfinate sulfohydrolase. Other names in common use include gene dszB-encoded hydrolase, 2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase, DszB, HBPSi desulfinase, 2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase, HPBS desulfinase, 2-(2-hydroxyphenyl)benzenesulfinate hydrolase, 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase, and 2-(2-hydroxyphenyl)benzenesulfinate desulfinase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DE2, 2DE3, and 2DE4.

[edit] References

IUBMB entry for 3.13.1.3
BRENDA references for 3.13.1.3 (Recommended.)
PubMed references for 3.13.1.3
PubMed Central references for 3.13.1.3
Google Scholar references for 3.13.1.3
Oldfield C, Pogrebinsky O, Simmonds J, Olson ES, Kulpa CF (Pt 9). "Elucidation of the metabolic pathway for dibenzothiophene desulphurization by Rhodococcus sp. strain IGTS8 (ATCC 53968)". Microbiology. 143: 2961–73. PMID 9308179.
Hirakawa Y, Suzuki M, Maruhashi K, Izumi Y, Kurane R (2002). "A novel enzyme, 2'-hydroxybiphenyl-2-sulfinate desulfinase (DszB), from a dibenzothiophene-desulfurizing bacterium Rhodococcus erythropolis KA2-5-1: gene overexpression and enzyme characterization". Biochim. Biophys. Acta. 1598: 122–30. PMID 12147352.
R, Ruckman E, Cody M, Mrachko GT (2003). "Purification and characterization of the aromatic desulfinase, 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase". Arch. Biochem. Biophys. 415: 14–23. doi:10.1016/S0003-9861(03)00230-3. PMID 12801508.