2',3'-cyclic-nucleotide 3'-phosphodiesterase

From Wikipedia, the free encyclopedia

In enzymology, a 2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) is an enzyme that catalyzes the chemical reaction

nucleoside 2',3'-cyclic phosphate + H₂O $\rightleftharpoons$ nucleoside 2'-phosphate

Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H₂O, whereas its product is nucleoside 2'-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase. Other names in common use include cyclic-CMP phosphodiesterase, 2',3'-cyclic AMP phosphodiesterase, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, CNPase, 2',3'-cyclic nucleotide phosphohydrolase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, and 2':3'-CNMP-3'-ase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1WOJ, 2I3E, and 2ILX.

[edit] References

IUBMB entry for 3.1.4.37
BRENDA references for 3.1.4.37 (Recommended.)
PubMed references for 3.1.4.37
PubMed Central references for 3.1.4.37
Google Scholar references for 3.1.4.37
Drummond GI, Iyer NT and Keith J (1962). "Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain". J. Biol. Chem. 237: 3535–3539.
Helfman DM, Kuo JF (1982). "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides". J. Biol. Chem. 257: 1044–7. PMID 6274851.
Helfman DM, Shoji M, Kuo JF (1981). "Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". J. Biol. Chem. 256: 6327–34. PMID 6263914.
Kurihara T, Nishizawa Y, Takahashi Y, Odani S (1981). "Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter". Biochem. J. 195: 153–7. PMID 6272743.
Nishizawa Y, Kurihara T, Takahashi Y (1980). "Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase". Biochem. J. 191: 71–82. PMID 6258586.