2',3'-cyclic-nucleotide 2'-phosphodiesterase

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In enzymology, a 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) is an enzyme that catalyzes the chemical reaction

nucleoside 2',3'-cyclic phosphate + H₂O $\rightleftharpoons$ nucleoside 3'-phosphate

Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H₂O, whereas its product is nucleoside 3'-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase. Other names in common use include ribonucleoside 2',3'-cyclic phosphate diesterase, 2',3 '-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleotidase, cyclic 2',3'-nucleotide 2'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic AMP 2'-phosphohydrolase, cyclic phosphodiesterase:3'-nucleotidase, 2',3'-cyclic nucleotide phosphohydrolase, 2':3'-cyclic phosphodiesterase, and 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.

[edit] References

IUBMB entry for 3.1.4.16
BRENDA references for 3.1.4.16 (Recommended.)
PubMed references for 3.1.4.16
PubMed Central references for 3.1.4.16
Google Scholar references for 3.1.4.16
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ANRAKU Y (1964). "A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. II. FURTHER STUDIES ON SUBSTRATE SPECIFICITY AND MODE OF ACTION OF THE ENZYME". J. Biol. Chem. 239: 3420–4. PMID 14245397.
Center MS, Behal FJ (1968). "A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis". J. Biol. Chem. 243: 138–43. PMID 4295113.
Olafson RW, Drummond GI, Lee JF (1969). "Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain". Can. J. Biochem. 47: 961–6. PMID 4310670.
Unemoto T, Hayashi M (1969). "Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus". Biochim. Biophys. Acta. 171: 89–102. PMID 4303200.