21-hydroxysteroid dehydrogenase (NAD+)

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In enzymology, a 21-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.150) is an enzyme that catalyzes the chemical reaction

pregnan-21-ol + NAD⁺ pregnan-21-al + NADH + H⁺

Thus, the two substrates of this enzyme are pregnan-21-ol and NAD⁺, whereas its 3 products are pregnan-21-al, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NAD+ 21-oxidoreductase. This enzyme is also called 21-hydroxysteroid dehydrogenase (NAD+).

[edit] References

• IUBMB entry for 1.1.1.150
• BRENDA references for 1.1.1.150 (Recommended.)
• PubMed references for 1.1.1.150
• PubMed Central references for 1.1.1.150
• Google Scholar references for 1.1.1.150
• MONDER C, WHITE A (1965). "THE 21-HYDROXYSTEROID DEHYDROGENASES OF LIVER. A NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE AND TWO NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASES". J. Biol. Chem. 240: 71–7. PMID 14253469. 

[edit] External links

The CAS registry number for this enzyme class is 37250-75-2.

• IUBMB entry for 1.1.1.150

• KEGG entry for 1.1.1.150

• BRENDA entry for 1.1.1.150

• NiceZyme view of 1.1.1.150

• EC2PDB: PDB structures for 1.1.1.150

• PRIAM entry for 1.1.1.150

• PUMA2 entry for 1.1.1.150

• IntEnz: Integrated Enzyme entry for 1.1.1.150

• MetaCyc entry for 1.1.1.150

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047007: 21-hydroxysteroid dehydrogenase (NAD+)

• AMIGO entry for GO code 0047007: 21-hydroxysteroid dehydrogenase (NAD+)