2-phosphosulfolactate phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a 2-phosphosulfolactate phosphatase (EC 3.1.3.71) is an enzyme that catalyzes the chemical reaction

(2R)-2-phospho-3-sulfolactate + H₂O (2R)-3-sulfolactate + phosphate

Thus, the two substrates of this enzyme are (2R)-2-phospho-3-sulfolactate and H₂O, whereas its two products are (2R)-3-sulfolactate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is (R)-2-phospho-3-sulfolactate phosphohydrolase. Other names in common use include (2R)-phosphosulfolactate phosphohydrolase, and ComB phosphatase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VR0.

[edit] References

• IUBMB entry for 3.1.3.71
• BRENDA references for 3.1.3.71 (Recommended.)
• PubMed references for 3.1.3.71
• PubMed Central references for 3.1.3.71
• Google Scholar references for 3.1.3.71
• Graham DE, Graupner M, Xu H, White RH (2001). "Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. A member of a new class of Mg(2+)-dependent acid phosphatases". Eur. J. Biochem. 268: 5176–88. doi:10.1046/j.0014-2956.2001.02451.x. PMID 11589710. 

[edit] External links

• IUBMB entry for 3.1.3.71

• KEGG entry for 3.1.3.71

• BRENDA entry for 3.1.3.71

• NiceZyme view of 3.1.3.71

• EC2PDB: PDB structures for 3.1.3.71

• PRIAM entry for 3.1.3.71

• PUMA2 entry for 3.1.3.71

• IntEnz: Integrated Enzyme entry for 3.1.3.71

• MetaCyc entry for 3.1.3.71

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050532: 2-phosphosulfolactate phosphatase

• AMIGO entry for GO code 0050532: 2-phosphosulfolactate phosphatase