2-oxopent-4-enoate hydratase

From Wikipedia, the free encyclopedia

In enzymology, a 2-oxopent-4-enoate hydratase (EC 4.2.1.80) is an enzyme that catalyzes the chemical reaction

4-hydroxy-2-oxopentanoate 2-oxopent-4-enoate + H₂O

Hence, this enzyme has one substrate, 4-hydroxy-2-oxopentanoate, and two products, 2-oxopent-4-enoate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming). Other names in common use include 2-keto-4-pentenoate hydratase, OEH, 2-keto-4-pentenoate (vinylpyruvate)hydratase, and 4-hydroxy-2-oxopentanoate hydro-lyase. This enzyme participates in 9 metabolic pathways: phenylalanine metabolism, benzoate degradation via hydroxylation, biphenyl degradation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, fluorene degradation, carbazole degradation, ethylbenzene degradation, and styrene degradation.

[edit] References

• IUBMB entry for 4.2.1.80
• BRENDA references for 4.2.1.80 (Recommended.)
• PubMed references for 4.2.1.80
• PubMed Central references for 4.2.1.80
• Google Scholar references for 4.2.1.80
• Kunz DA, Ribbons DW, Chapman PJ (1981). "Metabolism of allylglycine and cis-crotylglycine by Pseudomonas putida (arvilla) mt-2 harboring a TOL plasmid". J. Bacteriol. 148: 72–82. PMID 7287632. 

[edit] External links

The CAS registry number for this enzyme class is 64427-80-1.

• IUBMB entry for 4.2.1.80

• KEGG entry for 4.2.1.80

• BRENDA entry for 4.2.1.80

• NiceZyme view of 4.2.1.80

• EC2PDB: PDB structures for 4.2.1.80

• PRIAM entry for 4.2.1.80

• PUMA2 entry for 4.2.1.80

• IntEnz: Integrated Enzyme entry for 4.2.1.80

• MetaCyc entry for 4.2.1.80

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008684: 2-oxopent-4-enoate hydratase

• AMIGO entry for GO code 0008684: 2-oxopent-4-enoate hydratase