2-oxoisovalerate dehydrogenase (acylating)

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In enzymology, a 2-oxoisovalerate dehydrogenase (acylating) (EC 1.2.1.25) is an enzyme that catalyzes the chemical reaction

3-methyl-2-oxobutanoate + CoA + NAD⁺ 2-methylpropanoyl-CoA + CO₂ + NADH

The 3 substrates of this enzyme are 3-methyl-2-oxobutanoate, CoA, and NAD⁺, whereas its 3 products are 2-methylpropanoyl-CoA, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating). Other names in common use include 2-oxoisovalerate dehydrogenase, and alpha-ketoisovalerate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.

[edit] References

• IUBMB entry for 1.2.1.25
• BRENDA references for 1.2.1.25 (Recommended.)
• PubMed references for 1.2.1.25
• PubMed Central references for 1.2.1.25
• Google Scholar references for 1.2.1.25
• Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T (1969). "Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis". J. Biol. Chem. 244: 4437–47. PMID 4308861. 

[edit] External links

The CAS registry number for this enzyme class is 37211-61-3.

• IUBMB entry for 1.2.1.25

• KEGG entry for 1.2.1.25

• BRENDA entry for 1.2.1.25

• NiceZyme view of 1.2.1.25

• EC2PDB: PDB structures for 1.2.1.25

• PRIAM entry for 1.2.1.25

• PUMA2 entry for 1.2.1.25

• IntEnz: Integrated Enzyme entry for 1.2.1.25

• MetaCyc entry for 1.2.1.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047101: 2-oxoisovalerate dehydrogenase (acylating)

• AMIGO entry for GO code 0047101: 2-oxoisovalerate dehydrogenase (acylating)