2-oxoglutarate carboxylase

From Wikipedia, the free encyclopedia

In enzymology, a 2-oxoglutarate carboxylase (EC 6.4.1.7) is an enzyme that catalyzes the chemical reaction

ATP + 2-oxoglutarate + HCO₃- ADP + phosphate + oxalosuccinate

The 3 substrates of this enzyme are ATP, 2-oxoglutarate, and HCO3-, whereas its 3 products are ADP, phosphate, and oxalosuccinate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is '. Other names in common use include oxalosuccinate synthetase', carboxylating factor for ICDH (incorrect), CFI, and OGC.

[edit] References

• IUBMB entry for 6.4.1.7
• BRENDA references for 6.4.1.7 (Recommended.)
• PubMed references for 6.4.1.7
• PubMed Central references for 6.4.1.7
• Google Scholar references for 6.4.1.7
• Aoshima M, Ishii M, Igarashi Y (2004). "A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 51: 791–8. PMID 14731279. 
• Aoshima M, Igarashi Y (2006). "A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 62: 748–59. PMID 17076668. 

[edit] External links

• IUBMB entry for 6.4.1.7

• KEGG entry for 6.4.1.7

• BRENDA entry for 6.4.1.7

• NiceZyme view of 6.4.1.7

• EC2PDB: PDB structures for 6.4.1.7

• PRIAM entry for 6.4.1.7

• PUMA2 entry for 6.4.1.7

• IntEnz: Integrated Enzyme entry for 6.4.1.7

• MetaCyc entry for 6.4.1.7

• Atomic-resolution structures of enzymes belonging to this class