2-oxobutyrate synthase

From Wikipedia, the free encyclopedia

In enzymology, a 2-oxobutyrate synthase (EC 1.2.7.2) is an enzyme that catalyzes the chemical reaction

2-oxobutanoate + CoA + oxidized ferredoxin propanoyl-CoA + CO₂ + reduced ferredoxin

The 3 substrates of this enzyme are 2-oxobutanoate, CoA, and oxidized ferredoxin, whereas its 3 products are propanoyl-CoA, CO₂, and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propanoylating). Other names in common use include alpha-ketobutyrate-ferredoxin oxidoreductase, 2-ketobutyrate synthase, alpha-ketobutyrate synthase, 2-oxobutyrate-ferredoxin oxidoreductase, and 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating). This enzyme participates in propanoate metabolism.

[edit] References

• IUBMB entry for 1.2.7.2
• BRENDA references for 1.2.7.2 (Recommended.)
• PubMed references for 1.2.7.2
• PubMed Central references for 1.2.7.2
• Google Scholar references for 1.2.7.2
• Buchanan BB (1969). "Role of ferredoxin in the synthesis of alpha-ketobutyrate from propionyl coenzyme A and carbon dioxide by enzymes from photosynthetic and nonphotosynthetic bacteria". J. Biol. Chem. 244: 4218–23. PMID 5800441. 

[edit] External links

The CAS registry number for this enzyme class is 37251-04-0.

• IUBMB entry for 1.2.7.2

• KEGG entry for 1.2.7.2

• BRENDA entry for 1.2.7.2

• NiceZyme view of 1.2.7.2

• EC2PDB: PDB structures for 1.2.7.2

• PRIAM entry for 1.2.7.2

• PUMA2 entry for 1.2.7.2

• IntEnz: Integrated Enzyme entry for 1.2.7.2

• MetaCyc entry for 1.2.7.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018491: 2-oxobutyrate synthase

• AMIGO entry for GO code 0018491: 2-oxobutyrate synthase