2-oxoaldehyde dehydrogenase (NAD+)

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In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NAD⁺ + H₂O $\rightleftharpoons$ a 2-oxo acid + NADH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NAD+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NAD+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NAD+). This enzyme participates in pyruvate metabolism.

[edit] References

IUBMB entry for 1.2.1.23
BRENDA references for 1.2.1.23 (Recommended.)
PubMed references for 1.2.1.23
PubMed Central references for 1.2.1.23
Google Scholar references for 1.2.1.23
Monder C (1967). "Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 242: 4603–9. PMID 4383524.
Ray M, Ray S (1982). "On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase". J. Biol. Chem. 257: 10571–4. PMID 7107626.
Ray S, Ray M (1982). "Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 257: 10566–70. PMID 7107625.