2-oxoadipate reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2-oxoadipate reductase (EC 1.1.1.172) is an enzyme that catalyzes the chemical reaction

2-hydroxyadipate + NAD⁺ 2-oxoadipate + NADH + H⁺

Thus, the two substrates of this enzyme are 2-hydroxyadipate and NAD⁺, whereas its 3 products are 2-oxoadipate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-hydroxyadipate:NAD+ 2-oxidoreductase. Other names in common use include 2-ketoadipate reductase, alpha-ketoadipate reductase, and 2-ketoadipate reductase.

[edit] References

• IUBMB entry for 1.1.1.172
• BRENDA references for 1.1.1.172 (Recommended.)
• PubMed references for 1.1.1.172
• PubMed Central references for 1.1.1.172
• Google Scholar references for 1.1.1.172
• Suda T, Robinson JC, Fjellstedt TA (1976). "Purification and properties of alpha-ketoadipate reductase, a newly discovered enzyme from human placenta". Arch. Biochem. Biophys. 176: 610–20. doi:10.1016/0003-9861(76)90205-8. PMID 185965. 

[edit] External links

The CAS registry number for this enzyme class is 61116-21-0.

• IUBMB entry for 1.1.1.172

• KEGG entry for 1.1.1.172

• BRENDA entry for 1.1.1.172

• NiceZyme view of 1.1.1.172

• EC2PDB: PDB structures for 1.1.1.172

• PRIAM entry for 1.1.1.172

• PUMA2 entry for 1.1.1.172

• IntEnz: Integrated Enzyme entry for 1.1.1.172

• MetaCyc entry for 1.1.1.172

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047550: 2-oxoadipate reductase

• AMIGO entry for GO code 0047550: 2-oxoadipate reductase