2-oxo-acid reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2-oxo-acid reductase (EC 1.1.99.30) is an enzyme that catalyzes the chemical reaction

a (2R)-hydroxy-carboxylate + acceptor a 2-oxo-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are (2R)-hydroxy-carboxylate and acceptor, whereas its two products are 2-oxo-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (2R)-hydroxy-carboxylate:acceptor oxidoreductase. Other names in common use include (2R)-hydroxycarboxylate-viologen-oxidoreductase, HVOR, and 2-oxoacid reductase.

[edit] References

• IUBMB entry for 1.1.99.30
• BRENDA references for 1.1.99.30 (Recommended.)
• PubMed references for 1.1.99.30
• PubMed Central references for 1.1.99.30
• Google Scholar references for 1.1.99.30
• Trautwein T, Krauss F, Lottspeich F, Simon H (1994). "The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein". Eur. J. Biochem. 222: 1025–32. doi:10.1111/j.1432-1033.1994.tb18954.x. PMID 8026480. 
• Neumann S and Simon H (1985). "On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species". FEBS Lett. 167: 29–32. doi:10.1016/0014-5793(84)80826-1. 

[edit] External links

The CAS registry number for this enzyme class is 115299-99-5.

• IUBMB entry for 1.1.99.30

• KEGG entry for 1.1.99.30

• BRENDA entry for 1.1.99.30

• NiceZyme view of 1.1.99.30

• EC2PDB: PDB structures for 1.1.99.30

• PRIAM entry for 1.1.99.30

• PUMA2 entry for 1.1.99.30

• IntEnz: Integrated Enzyme entry for 1.1.99.30

• MetaCyc entry for 1.1.99.30

• Atomic-resolution structures of enzymes belonging to this class