2-methyleneglutarate mutase

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In enzymology, a 2-methyleneglutarate mutase (EC 5.4.99.4) is an enzyme that catalyzes the chemical reaction

2-methyleneglutarate $\rightleftharpoons$ 2-methylene-3-methylsuccinate

Hence, this enzyme has one substrate, 2-methyleneglutarate, and one product, 2-methylene-3-methylsuccinate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methyleneglutarate carboxy-methylenemethylmutase. This enzyme is also called alpha-methyleneglutarate mutase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide.

[edit] References

IUBMB entry for 5.4.99.4
BRENDA references for 5.4.99.4 (Recommended.)
PubMed references for 5.4.99.4
PubMed Central references for 5.4.99.4
Google Scholar references for 5.4.99.4
Kung HF, Cederbaum S, Tsai L, Stadtman TC (1970). "Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid". Proc. Natl. Acad. Sci. U. S. A. 65: 978–84. doi:10.1073/pnas.65.4.978. PMID 5266166.
Kung HF, Stadtman TC (1971). "Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase". J. Biol. Chem. 246: 3378–88. PMID 5574401.